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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDC6 All Species: 22.73
Human Site: T409 Identified Species: 38.46
UniProt: Q99741 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99741 NP_001245.1 560 62720 T409 E S D V K S Q T I L K P L S E
Chimpanzee Pan troglodytes XP_001170406 560 62717 T409 E S D V K S Q T I L K P L S E
Rhesus Macaque Macaca mulatta XP_001096756 559 62520 Q408 V E S D V K S Q T V L K P L S
Dog Lupus familis XP_537648 559 62507 T408 E S D V K S Q T V L K P L S E
Cat Felis silvestris
Mouse Mus musculus O89033 562 62595 T411 E S D V R S Q T V L K P L S E
Rat Rattus norvegicus NP_001101768 561 62295 T410 E S D V R S Q T V L K P L S E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519126 361 39672 G225 E G A S K P A G R D V V R K L
Chicken Gallus gallus
Frog Xenopus laevis NP_001081844 554 60731 K404 V R G Q T V L K P L T E C L S
Zebra Danio Brachydanio rerio NP_001120805 561 61262 V410 C R R A V E I V E A G D R S K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_648247 662 75116 A508 E K E F N M K A L Q L E G K D
Honey Bee Apis mellifera XP_625142 549 62089 Q397 T E S H K L A Q I L Q P S N E
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus NP_999666 582 64455 I421 R K A L L S P I K S S P R K S
Poplar Tree Populus trichocarpa XP_002299817 498 55546 T362 E A E L R E S T S I L P S D K
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P09119 513 58018 S377 T T S P V K K S Y P E P Q G K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 96 89.1 N.A. 79.5 80 N.A. 45.3 N.A. 63.7 49 N.A. 33.9 36 N.A. 40
Protein Similarity: 100 100 97.5 93.5 N.A. 87.3 88.9 N.A. 52.8 N.A. 77.5 67.3 N.A. 52.1 57.3 N.A. 58.5
P-Site Identity: 100 100 0 93.3 N.A. 86.6 86.6 N.A. 13.3 N.A. 6.6 6.6 N.A. 6.6 33.3 N.A. 13.3
P-Site Similarity: 100 100 6.6 100 N.A. 100 100 N.A. 13.3 N.A. 6.6 13.3 N.A. 33.3 46.6 N.A. 20
Percent
Protein Identity: 25.8 N.A. N.A. N.A. 20.1 N.A.
Protein Similarity: 46.4 N.A. N.A. N.A. 41.2 N.A.
P-Site Identity: 20 N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: 60 N.A. N.A. N.A. 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 15 8 0 0 15 8 0 8 0 0 0 0 0 % A
% Cys: 8 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % C
% Asp: 0 0 36 8 0 0 0 0 0 8 0 8 0 8 8 % D
% Glu: 58 15 15 0 0 15 0 0 8 0 8 15 0 0 43 % E
% Phe: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 8 8 0 0 0 0 8 0 0 8 0 8 8 0 % G
% His: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 8 8 22 8 0 0 0 0 0 % I
% Lys: 0 15 0 0 36 15 15 8 8 0 36 8 0 22 22 % K
% Leu: 0 0 0 15 8 8 8 0 8 50 22 0 36 15 8 % L
% Met: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 8 0 0 0 0 0 0 0 0 8 0 % N
% Pro: 0 0 0 8 0 8 8 0 8 8 0 65 8 0 0 % P
% Gln: 0 0 0 8 0 0 36 15 0 8 8 0 8 0 0 % Q
% Arg: 8 15 8 0 22 0 0 0 8 0 0 0 22 0 0 % R
% Ser: 0 36 22 8 0 43 15 8 8 8 8 0 15 43 22 % S
% Thr: 15 8 0 0 8 0 0 43 8 0 8 0 0 0 0 % T
% Val: 15 0 0 36 22 8 0 8 22 8 8 8 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _